Launch is scheduled for 22:00 BST and you can watch the live launch of the Falcon 9 Rocket carrying the ANASIS-II Mission below.
If the trajectory is right, the newly launched spacecraft may be visible over the UK 15 minutes later. As either an individual object or collection of launch elements travelling together.
The craft will appear over the UK if all goes to plan and trajectory allows at approximately 22:15 BST and will pass over from a westerly direction heading east. Exact trajectory, times, or if indeed it will be visible aren’t known at present so good luck.
Once you have watched the launch and looked for the spacecraft, you can see the ISS in UK skies after. See here for times and follow @VirtualAstro for alerts and info.
More info about the mission from the official SpaceX website